Welcome to the YuanST (Spatial-Temporal) Lab at the Institute of Science and Technology for Brain-inspired Intelligence (ISTBI), Fudan University. We develop computational methods and spatial omics technologies to understand complex biological systems through multimodal data integration and spatiotemporal analysis. We focus on three interconnected areas: optimizing spatial omics experimental design through computational approaches, developing computational methods for integrating multimodal spatiotemporal data to represent tissue microenvironment, and mining these spatiotemporal data to extract meaningful biological insights and biomedical applications.